Altered Dynamics of Intestinal Cell Maturation in Apc Mice
نویسندگان
چکیده
Authors' Structural Medicine; 5 Unit, Feins System, M Research, Note: Supp Online (http
منابع مشابه
Molecular and Cellular Pathobiology Altered Dynamics of Intestinal Cell Maturation in Apc Mice
Novel imaging of active transcription sites in interphase nuclei of intestinal epithelial cells in situ showed that key genes associated with Wnt and Notch signaling were dynamically regulated as the cells underwent normal maturation during their migration along the mouse crypt-villus axis (CVA). However, oscillating patterns of activation of these genes were displaced along this axis in the hi...
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Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21 increases the frequency and size of intestinal tumors in Apc1638 mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation is associated with altered cell maturation in the intestinal mucosa of the p21-deficient mice...
متن کاملThe absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.
Lysophosphatidic acid (LPA) is a lipid mediator that mediates several effects that promote cancer progress. The LPA receptor type 2 (LPA(2)) expression is often elevated in several types of cancers, including colorectal cancer (CRC). In this study, we investigated the role of LPA(2) in the development of intestinal adenomas by comparing Apc(Min/+) mice with Apc(Min/+)/Lpar2(-/-) mice. There wer...
متن کاملIntestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells.
BACKGROUND Adenomatous polyposis coli (APC) are important in maintaining normal epithelial mucosa. Intestinal tissues with mutations in Apc have disturbed cell proliferation, differentiation and migration. Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively. MATERIALS AND METHODS ...
متن کاملThe absence of LPA receptor 2 reduces the tumorigenesis by Apc mutation in the intestine
Lin S, Lee S, Shim H, Chun J, Yun CC. The absence of LPA receptor 2 reduces the tumorigenesis by Apc mutation in the intestine. Am J Physiol Gastrointest Liver Physiol 299: G1128–G1138, 2010. First published August 19, 2010; doi:10.1152/ajpgi.00321.2010.—Lysophosphatidic acid (LPA) is a lipid mediator that mediates several effects that promote cancer progress. The LPA receptor type 2 (LPA2) exp...
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